ALEXANDER R. GOTTSCHALK

This study identifies NRA-1 as an activity-dependent regulator of cholinergic signalling and sensory integration in C. elegans, showing it modulates receptor gating and behaviour.

The paper uses all-optical methods to study gap junction coupling in C. elegans muscle cells, showing how specific innexins affect synchronization and locomotion.

The paper identifies a KCR1 variant, C29D, that maintains stable potassium selectivity and provides reliable optogenetic inhibition across species and conditions.

The paper identifies in situ structures of gap junctions in C. elegans using cryo-electron tomography and sub-tomogram averaging, revealing a cytosolic cap formed by the stomatin UNC-1 protein.

This study investigates the role of FLWR-1 in synaptic vesicle recycling and neuronal activity in C. elegans, finding it regulates Ca2+ levels via PMCA and affects excitation-inhibition balance.

The paper identifies neurons and molecular mechanisms involved in noxious light sensation in C. elegans, showing AVG as a key neuron for escape behavior and the role of NLP-10 in maintaining responsiveness.

This study characterizes AkVAL, a bistable opsin from the flashlight fish, showing its ability to control neuronal activity and body movement in response to light cycles, suggesting its potential as an optogenetic tool.

The paper shows two neuropeptides from a single neuron pair in C. elegans have opposing effects on locomotion, with one inhibiting the release of the other through autocrine feedback.

The paper shows that loss of neuropeptide signaling in C. elegans leads to increased muscle excitability via CaV1 channels to compensate for reduced cholinergic transmission.

The paper investigates neuropeptide regulation of neuromuscular signaling in zebrafish, showing that cAMP signaling enhances synaptic transmission and that neuropeptide mutants exhibit altered locomotion and synaptic properties.

The paper investigates how RIM and RIM-binding proteins regulate synaptic transmission by localizing Cav2 channels in C. elegans neuromuscular junctions, showing differential effects on cholinergic and GABAergic transmission.

This study evaluates the use of potassium-selective channelrhodopsins (KCRs) for hyperpolarizing C. elegans cells, finding that their effectiveness depends on illumination parameters and can sometimes induce depolarization.

This paper introduces an optogenetic voltage-clamp technique for precise control of cellular voltage in live animals, demonstrating its application in C. elegans and rat neurons.

The paper introduces pOpsicle, an all-optical system for tracking synaptic vesicle recycling using pH-sensitive fluorescent proteins and optogenetic stimulation in C. elegans.

The paper investigates how two interneurons, RIS and RIM, coordinate electrical and chemical signaling to control motor state transitions in C. elegans.

This paper introduces optoSynC, an optogenetic tool that rapidly and reversibly silences synaptic transmission by clustering synaptic vesicles in C. elegans.

BiPOLES is an optogenetic tool that allows bidirectional control of neuronal activity using two different light colors, enabling both excitation and inhibition of the same neurons in a single experiment.

This study shows that synapsin SNN-1 is required for cAMP-dependent neuropeptide release in C. elegans motor neurons by capturing dense core vesicles at synapses.

The paper identifies EGFR signaling in the RIS neuron and its indirect activation via the ALA neuron as mechanisms for sleep induction following cellular stress in C. elegans.

The paper evaluates voltage imaging tools in C. elegans, showing voltage sensitivity and depolarization differences in muscles and pharynx.

The paper introduces a GFP-based cGMP sensor, WincG2, for real-time imaging of cGMP dynamics in intact C. elegans, showing its sensitivity to cGMP changes and responses to NaCl and SDS.

This study identifies the functional role of AS motor neurons in coordinating locomotion in C. elegans by integrating signals from premotor interneurons and mediating body wave propagation.

The paper shows that overlapping neural circuits in C. elegans enable robust and flexible thermotaxis behavior through compensatory mechanisms and context-dependent regulation.