Silvan Spiri

Tom70-mediated mitochondria-nuclear envelope contacts regulate nuclear pore complex inheritance during gametogenesis

The paper identifies Tom70 as a regulator of nuclear pore complex exclusion during gametogenesis in yeast by mediating mitochondria-nuclear envelope contacts.

Conserved role of EGFR signaling in apoptotic cell recognition and processing across different phagocytes

This study shows EGFR signaling is essential for efferocytosis in C. elegans and zebrafish, with EGF acting as an engulfment signal.

Blm10 scaffolds 14-3-3 adaptors to the proteasome, and maintains cellular proteostatic balance and gamete quality

This study identifies Blm10 as a proteasome-associated protein that modulates proteasome activity and maintains proteostasis and gamete quality in yeast.

A role for selective autophagy of the ER in gametogenic rejuvenation revealed by microfluidics-based lifespan profiling

The paper introduces a high-throughput microfluidic assay to study gametogenic rejuvenation in yeast and identifies Atg39 and Atg40 as molecular determinants of lifespan resetting.

Reciprocal EGFR signaling in the Anchor Cell ensures precise inter-organ connection during C. elegans vulval morphogenesis

The paper identifies a reciprocal EGFR signaling mechanism in the C. elegans anchor cell that ensures precise alignment and connection between the uterus and vulva during development.

Microfluidic-based imaging of complete C. elegans larval development

This paper introduces a microfluidic imaging method for long-term, stable, and parallel live-imaging of C. elegans larval development, enabling observation of previously inaccessible processes.

Epidermal Growth Factor signaling acts directly and through a sedation neuron to depolarizes a sleep-active neuron following cellular stress

The paper identifies EGFR signaling in the RIS neuron and its indirect activation via the ALA neuron as mechanisms for sleep induction following cellular stress in C. elegans.