Securin and cyclin B1-CDK1, but not SGO2, regulate separase activity during meiosis I in mouse oocytes
Benjamin Wetherall, David M. Bulmer, Alexandra Sarginson, Christopher Thomas, Suzanne Madgwick
This study shows that securin and cyclin B1-CDK1, but not SGO2, independently inhibit separase during meiosis I in mouse oocytes, and their combined loss leads to premature separase activation.
bioRxiv · Jan 6, 2025 · PreprintCell Biology