Ian A. Prior

Proteomics- and BRET-screens identify SPRY2 as Ras effector that impacts its membrane organisation

The paper identifies SPRY2 as a novel K-Ras effector that impacts its membrane organisation through proteomics and BRET screens.

Hypoxia-induced regulation of zDHHC23 opens avenues for new biomarkers for NON MYCN-amplified neuroblastoma

The paper identifies zDHHC23 as a hypoxia-responsive gene associated with metastasis in non-MYCN amplified neuroblastoma, suggesting it as a potential biomarker and therapeutic target.

Nucleophosmin mutations lead to abnormal, but reversible, nucleoli architecture and aggregate formation - implications for NPM1-targeting therapies in AML

This study shows that NPM1 mutations cause abnormal nucleoli structure and reversible aggregates in AML, suggesting new therapeutic targets.

Rules of engagement for condensins and cohesins guide mitotic chromosome formation

In DT40 cells, condensins displace extrusive cohesin, bypass cohesive cohesin and stall against each other while extruding ~1-3 kb/sec, yielding irregular helical chromatids of consecutive loops.

The Chromosome Periphery is an Essential Compartment of Oocyte Chromosomes

This study investigates the role of the chromosome periphery in oocyte meiosis, showing its impact on chromosome structure and meiotic progression in human and mouse oocytes.

ER stress-linked autophagy stabilizes apoptosis effector PERP and triggers its co-localization with SERCA2b at ER-plasma membrane junctions

This study identifies a novel interaction between PERP and SERCA2b at ER-PM junctions under ER stress, linking autophagy to apoptosis.

Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion

This study shows that Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and drives breast cancer invasion by coordinating matrix stiffness and transcriptional reprogramming.

Eps8 is a convergence point integrating EGFR and integrin trafficking and crosstalk

This study identifies Eps8 as a key integrator of EGFR and integrin trafficking, showing it regulates their endocytosis and adhesion complex dynamics.