Mapping cellular targets of covalent cancer drugs in the entire mammalian body
Zhengyuan Pang, Verina H. Leung, Cailynn C. Wang, Ahmadreza Attarpour, Anthony Rinaldi, Hanbing Shen, María Dolores Moya-Garzón, Logan H. Sigua, Claire Rammel, Alexandra Selke, Christopher Glynn, Melaina Yender, Senhan Xu, Javid J. Moslehi, Peng Wu, , Ye Li
This paper develops vCATCH to map covalent drug targets across the entire mouse body, revealing new tissue and cell type engagements for afatinib and ibrutinib.
Cell · Dec 22, 2025Peer-reviewedPharmacology & Toxicology