Author

Peng Wu

Scripps Research InstituteORCID 0000-0002-9128-9027Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Peng Wu5 papers · Guangxi Academy of Agricultural Science

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:imaging· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Ding ZhangiD· 2 shared Ahmadreza AttarpouriD· 1 shared Alexander G. GabiboviD· 1 shared Alexandra Selke· 1 shared Alexey V. StepanoviD· 1 shared Anthony RinaldiiD· 1 shared Benjamin F. CravattiD· 1 shared Cailynn C. Wang· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Ding ZhangORCID

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Author profile →

3 papers

Recent·Most cited

Affinity Maturation Enables Dual Targeting of Cancer-Associated MUC1-Tn/STn and Drives Potent Tumor Control

Jinfeng Ye, Xueyong Zhu, Huinan Lu, Jessica D. Coppola, Ding Zhang, Yinping Tian, Zhuo Yang, Shereen Chung, Leigh-Anne Cui, Jinghao Zhi, Liuqing Wen, Jianzhong Xi, Ian A. Wilson, Joseph Jardine, Peng Wu

This study affinity-matures an antibody to recognize both MUC1-Tn and MUC1-STn glycoforms, enhancing its efficacy against heterogeneous tumors.

bioRxiv · Oct 26, 2026 · PreprintCancer Biology

Mapping cellular targets of covalent cancer drugs in the entire mammalian body

Zhengyuan Pang, Verina H. Leung, Cailynn C. Wang, Ahmadreza Attarpour, Anthony Rinaldi, Hanbing Shen, María Dolores Moya-Garzón, Logan H. Sigua, Claire Rammel, Alexandra Selke, Christopher Glynn, Melaina Yender, Senhan Xu, Javid J. Moslehi, Peng Wu, , Ye Li

This paper develops vCATCH to map covalent drug targets across the entire mouse body, revealing new tissue and cell type engagements for afatinib and ibrutinib.

Cell · Dec 22, 2025Peer-reviewedPharmacology & Toxicology

Targeting CD45 by gene-edited CAR-T cells for leukemia eradication and hematopoietic stem cell transplantation preconditioning

Valeria M. Stepanova, Dmitry V. Volkov, Daria S. Osipova, Wenjian Wang, Yingqin Hou, Dmitry Pershin, Maria Fadeeva, Ekaterina A. Malakhova, Elena A. Kulakovskaya, LYU Cuicui, Zhao Mingfeng, Hongkai Zhang, Jia Xie, Ding Zhang, Ilgar Z. Mamedov, , Alexey V. Stepanov

This paper demonstrates the preclinical efficacy of CD45-targeting CAR T and NK cells for leukemia treatment and HSCT preconditioning, showing reduced fratricide through gene editing.

Molecular Therapy Oncology · Jun 27, 2024Peer-reviewedMolecular Biology