Logan H. Sigua

This paper develops vCATCH to map covalent drug targets across the entire mouse body, revealing new tissue and cell type engagements for afatinib and ibrutinib.

This study develops a kinetic scout approach to accelerate targeted protein degrader development by tuning ligand residence time through chemical proteomics and mechanistic assays.

This study shows that BRD9 and ncBAF complexes maintain somatic cell identity and hinder reprogramming, with BRD9 inhibition increasing iPSC generation efficiency.