Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone
Vivianne E. Morrison, Matthew Houpert, Jonathan B. Trapani, Asa A. Brockman, Philip J. Kingsley, Ketaki A. Katdare, Hillary M. Layden, Gabriela Nguena‐Jones, Alexandra Trevisan, Kathleen A. Maguire‐Zeiss, Lawrence J. Marnett, Gregory Jaye Bix, Rebecca A. Ihrie, Bruce Douglas Carter
This paper shows that Jedi-1-mediated phagocytosis by microglia in the V-SVZ promotes neurogenesis by suppressing inflammatory pathways, and its loss leads to neuroinflammation and reduced neural precursor proliferation.
Cell Reports · Nov 1, 2023Peer-reviewedNeuroscience