The paper identifies expression-driven genetic dependency targets for precision oncology using a Bayesian approach, revealing new druggable genes and validating their therapeutic potential.

bioRxiv · Oct 17, 2024 · PreprintGenomics

Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone

Vivianne E. Morrison, Matthew Houpert, Jonathan B. Trapani, Asa A. Brockman, Philip J. Kingsley, Ketaki A. Katdare, Hillary M. Layden, Gabriela Nguena‐Jones, Alexandra Trevisan, Kathleen A. Maguire‐Zeiss, Lawrence J. Marnett, Gregory Jaye Bix, Rebecca A. Ihrie, Bruce Douglas Carter

This paper shows that Jedi-1-mediated phagocytosis by microglia in the V-SVZ promotes neurogenesis by suppressing inflammatory pathways, and its loss leads to neuroinflammation and reduced neural precursor proliferation.

Cell Reports · Nov 1, 2023Peer-reviewedNeuroscience

PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, andRNA polymerase pause release at select gene targets

Susu Zhang, Jing Wang, Qi Liu, William Hayes McDonald, Monica L. Bomber, Hillary M. Layden, Jacob D. Ellis, Scott C. Borinstein, Scott W. Hiebert, Kristy R. Stengel

This study uses a chemical-genetic approach to show that PAX3-FOXO1 regulates enhancer architecture, eRNA transcription, and RNA polymerase pause release at specific gene targets.

Molecular Cell · Nov 16, 2022Peer-reviewedMolecular Biology