Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction
Einar Kleinhans Krogsaeter, Justin McKetney, Leopoldo Valiente‐Banuet, Angelica Marquez, Alexandra Willis, Zeynep Cakir, Erica J. Stevenson, Gwendolyn Μ. Jang, Antara T. Rao, Emmy Li, Anton Zhou, Anjani Attili, Timothy S. Chang, Martin Kampmann, Yadong Huang, , Danielle L. Swaney
This study identifies lysosomal proteome changes caused by apoE4, linking them to lysosomal dysfunction and Alzheimer's disease pathology.
Autophagy · Oct 17, 2025Peer-reviewedNeuroscience