Emmy Li

Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction

This study identifies lysosomal proteome changes caused by apoE4, linking them to lysosomal dysfunction and Alzheimer's disease pathology.

Perturbing RNA localization for functional study in neurons

This study introduces CRISPR-TO to manipulate RNA localization in neurons, showing it affects neurite outgrowth and axonal regeneration.

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions

The paper develops iAssembloids to study neuron-glia interactions using CRISPRi screens and finds GSK3β inhibits NRF2-mediated oxidative stress response and APOE-4 promotes neuronal activity.

A reference induced pluripotent stem cell line for large-scale collaborative studies

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states

The paper uses CRISPRi screens and single-cell transcriptomics in human astrocytes to identify regulators of inflammatory reactive states and their relevance in disease.

Molecular characterization of selectively vulnerable neurons in Alzheimer's Disease

The paper identifies molecular signatures of selectively vulnerable neurons in Alzheimer's Disease using single-nucleus RNA sequencing and validates findings with neuropathological methods.

Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury

The paper shows that peripheral sensory neurons undergo consistent transcriptional changes after axonal injury, which promote regeneration but also suppress cell identity, with Atf3 playing a key role.