Yadong Huang

APOE4 disrupts the central dogma by arresting neuronal proteome dynamics

This study shows APOE4 disrupts neuronal proteome dynamics by impairing proteostasis, leading to protein accumulation and cellular stress before Alzheimer's disease onset.

Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimers Disease Pathogenesis

This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.

Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model

Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease

This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.

Tri-AD: Hippocampal cell-type-specific responses to age, sex and APOE genotype

The paper investigates how age, sex, and APOE genotype affect hippocampal cell-type-specific gene expression and communication in mice, revealing sex-divergent effects of APOE4.

Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer's disease mouse model

This study shows neuronal APOE4 alone can drive tau pathology, neurodegeneration, and neuroinflammation in a mouse model, similar to a human APOE4 knock-in model.

Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction

This study identifies lysosomal proteome changes caused by apoE4, linking them to lysosomal dysfunction and Alzheimer's disease pathology.

Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease

The paper identifies a cell-type-directed combination therapy for Alzheimer's disease using single-cell transcriptomics and drug databases, showing improved memory and reduced pathologies in a mouse model.

Waveform-based classification of dentate spikes

This paper develops an unsupervised method to classify dentate spikes into types 1 and 2 based on waveform features, showing high accuracy and revealing differences in DS characteristics between apoE3 and apoE4 mice.

Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model

The paper investigates the role of microglia in APOE4-driven Alzheimer's pathology using a chimeric model, finding that microglia are required for APOE4-induced pathologies.

APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia

The paper links APOE4/4 genotype to lipid droplet accumulation in Alzheimer's microglia, showing its role in neurotoxicity through triglyceride synthesis and Tau phosphorylation.

Early and lifelong effects of APOE4 on neuronal gene expression networks relevant to Alzheimer's disease

This study identifies early and persistent effects of APOE4 on neuronal gene expression networks in aging, suggesting the need for early interventions in Alzheimer's disease.

Dentate Gyrus and CA3 GABAergic Interneurons Bidirectionally Modulate Signatures of Internal and External Drive to CA1

The paper shows that PV+ and SST+ interneurons in the DG and CA3 differentially modulate information flow to CA1 by altering coupling signatures from CA3 and entorhinal cortex.

Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women with Alzheimer's Disease

This study identifies sex-specific immune dysregulation in Alzheimer's Disease through meta-analysis of gene expression in brain and blood samples.

Aβ initiates brain hypometabolism and network dysfunction via NOX2 activation: a potential onset mechanism of Alzheimer's disease

Aβ1-42 induces brain hypometabolism, network hyperactivity, and behavioral changes via NOX2-mediated oxidative stress, suggesting a novel therapeutic target for Alzheimer's disease treatment.

Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer’s Disease Mouse Model

The paper shows that reduced hippocampal sharp-wave ripple abundance and associated slow gamma power in Alzheimer’s disease mouse models predict later spatial memory impairments.