Author
Gladstone InstitutesORCID 0000-0002-1269-018XUnclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Dennis R. Tabuena, Sung-Soo Jang, Brian P. Grone…·Misha Y. Zilberter
This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.
Einar Kleinhans Krogsaeter, Justin McKetney, Leopoldo Valiente‐Banuet…·Danielle L. Swaney
This study identifies lysosomal proteome changes caused by apoE4, linking them to lysosomal dysfunction and Alzheimer's disease pathology.
Yaqiao Li, Carlota Pereda Serras, Jessica R. Blumenfeld…·Marina Sirota
The paper identifies a cell-type-directed combination therapy for Alzheimer's disease using single-cell transcriptomics and drug databases, showing improved memory and reduced pathologies in a mouse model.
Antara T. Rao, Nuo Chen, Min Joo Kim…·Yadong Huang
The paper investigates the role of microglia in APOE4-driven Alzheimer's pathology using a chimeric model, finding that microglia are required for APOE4-induced pathologies.
Emily A Aery Jones, Antara T. Rao, Misha Y. Zilberter…·Loren M. Frank
The paper shows that PV+ and SST+ interneurons in the DG and CA3 differentially modulate information flow to CA1 by altering coupling signatures from CA3 and entorhinal cortex.