Justin McKetney

Tau is an m6A-associated RNA binding protein that causes RNA dysregulation in disease

The paper identifies tau as an m6A-associated RNA binding protein that causes RNA dysregulation in MAPT coding-variant patients and V337M iNeurons.

APOE4 disrupts the central dogma by arresting neuronal proteome dynamics

This study shows APOE4 disrupts neuronal proteome dynamics by impairing proteostasis, leading to protein accumulation and cellular stress before Alzheimer's disease onset.

Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation

The paper uses multi-omic analysis to study MAPT V337M neurons, finding altered axonogenesis and tau phosphorylation, with p38 MAPK pathway involvement in tau phosphorylation in V337M neurons.

Extracellular matrix proteolysis maintains synapse plasticity during brain development

The paper shows ECM proteolysis, specifically via MMP14 and brevican, maintains dynamic synapse plasticity during brain development in zebrafish and human iPSC-derived cultures.

Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction

This study identifies lysosomal proteome changes caused by apoE4, linking them to lysosomal dysfunction and Alzheimer's disease pathology.

Deep Learning Predicts Non-Normal Peptide FAIMS Mobility Distributions Directly from Sequence

The paper develops deep learning models to predict FAIMS ion mobility of peptides from sequence, achieving high F2 score on E. coli peptides.

A foundational atlas of autism protein interactions reveals molecular convergence

The paper constructs a PPI network of 100 high-confidence ASD genes, identifies novel interactions, and uses AlphaFold-Multimer to prioritize variants for functional validation in organoids.