Author

Zeynep Cakir

Gladstone InstitutesORCID 0000-0002-5280-2289Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Danielle L. SwaneyiD· 2 shared Gwendolyn Μ. JangiD· 2 shared Nevan J. KroganiD· 2 shared Adam L. OrriD· 1 shared Alexandra Willis· 1 shared Alexandre da Cruz· 1 shared Angelica Marquez· 1 shared Anjani Attili· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Danielle L. SwaneyORCID

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2 papers

Recent·Most cited

Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction

Einar Kleinhans Krogsaeter, Justin McKetney, Leopoldo Valiente‐Banuet, Angelica Marquez, Alexandra Willis, Zeynep Cakir, Erica J. Stevenson, Gwendolyn Μ. Jang, Antara T. Rao, Emmy Li, Anton Zhou, Anjani Attili, Timothy S. Chang, Martin Kampmann, Yadong Huang, , Danielle L. Swaney

This study identifies lysosomal proteome changes caused by apoE4, linking them to lysosomal dysfunction and Alzheimer's disease pathology.

Autophagy · Oct 17, 2025Peer-reviewedNeuroscience

Quantitative proteomic analysis reveals apoE4-dependent phosphorylation of the actin-regulating protein VASP

Zeynep Cakir, Samuel J. Lord, Yuan Zhou, Gwendolyn Μ. Jang, Benjamin J. Polacco, Manon Eckhardt, David Jimenez‐Morales, Billy W. Newton, Adam L. Orr, Jeffrey R. Johnson, Alexandre da Cruz, R. Dyche Mullins, Nevan J. Krogan, Robert W. Mahley, Danielle L. Swaney

The paper shows apoE4 increases VASP phosphorylation, disrupting actin interactions and affecting neurite outgrowth in Neuro-2a cells.

bioRxiv · Jun 6, 2022 · PreprintNeuroscience