Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells
Kristen S. Young, Govinda R Hancock, Emma C. Fink, Alexandra Zigrossi, Brenna Flowers, D. A. Cooper, Vy T. Nguyen, Millie Martinez, Khin Su Mon, Maarten C. Bosland, Donald R. Zak, Austin P Runde, Marina Nasrin Sharifi, Irida Kastrati, David D. L. Minh, , Sean William Fanning
This study investigates how a novel SERM, T6I-29, downregulates DKK1 in Y537S ESR1 mutant breast cancer cells and identifies DKK1 as a potential therapeutic target.
Breast Cancer Research · Jan 17, 2025Peer-reviewedCancer Biology