David D. L. Minh

Linking biochemical and cellular efficacy of MERS coronavirus main protease inhibitors

The paper compares three data analysis methods for MERS-CoV MPro inhibitors, finding that modeling the complete concentration-response curve best predicts cellular efficacy.

Digoxin Inhibits Bax{triangleup}2-induced Neuronal Cell Death

This study identifies digoxin as a compound that blocks Bax{Delta}2-induced neuronal cell death at nanomolar concentrations, independent of its cardiac effects.

Enzyme kinetics model for the coronavirus main protease including dimerization and ligand binding

The paper develops a kinetic model of the coronavirus main protease incorporating dimerization and ligand binding, showing how inhibitors and substrates affect enzyme activity differently.

Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells

This study investigates how a novel SERM, T6I-29, downregulates DKK1 in Y537S ESR1 mutant breast cancer cells and identifies DKK1 as a potential therapeutic target.

Intracellular pocket conformations determine signaling through the μ opioid receptor

The paper uses a machine learning model to predict signaling efficacy through the μ opioid receptor by analyzing intracellular pocket conformations.