Author

Donald R. Zak

Loyola University ChicagoORCID 0000-0002-9730-7337Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

A. Stuart GrandyiD· 1 shared Alexandra Zigrossi· 1 shared Austin P RundeiD· 1 shared Brenna FlowersiD· 1 shared Brooke E. PropsoniD· 1 shared D. A. Cooper· 1 shared David D. L. MinhiD· 1 shared Emma C. FinkiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperEcology

A. Stuart GrandyORCID

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2 papers

Recent·Most cited

Anthropogenic nitrogen deposition restructures decomposing microbial communities, altering SOM molecular composition, but not molecular complexity or diversity

Brooke E. Propson, William A. Argiroff, Grace Ann Cagle, Rima A. Upchurch, Donald R. Zak, A. Stuart Grandy, Zachary B. Freedman

This study examines how anthropogenic nitrogen deposition affects microbial communities and soil organic matter (SOM) molecular composition during root decomposition.

npj Soil Ecology · Sep 9, 2026Peer-reviewedEcology

Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells

Kristen S. Young, Govinda R Hancock, Emma C. Fink, Alexandra Zigrossi, Brenna Flowers, D. A. Cooper, Vy T. Nguyen, Millie Martinez, Khin Su Mon, Maarten C. Bosland, Donald R. Zak, Austin P Runde, Marina Nasrin Sharifi, Irida Kastrati, David D. L. Minh, , Sean William Fanning

This study investigates how a novel SERM, T6I-29, downregulates DKK1 in Y537S ESR1 mutant breast cancer cells and identifies DKK1 as a potential therapeutic target.

Breast Cancer Research · Jan 17, 2025Peer-reviewedCancer Biology