Rational design of a protein-protein interaction inhibitor that activates Protein Tyrosine Phosphatase 1B.
Avinash D. Londhe, Sophie Rizzo, Syed Husain Mustafa Rizvi, Alexandre Bergeron, Reddy Sudheer Sagabala, Nilesh K. Banavali, Damien Thévenin, Benoît Boivin
This paper designs a PPI inhibitor peptide that activates PTP1B by disrupting its interaction with the 14-3-3ζ complex, leading to reduced EGFR phosphorylation and cancer cell viability.
bioRxiv · Mar 21, 2026 · PreprintBiochemistry