BiochemistrybioRxivPreprint
Rational design of a protein-protein interaction inhibitor that activates Protein Tyrosine Phosphatase 1B.
Avinash D. Londhe, Sophie Rizzo, Syed Husain Mustafa Rizvi…·Benoît Boivin
This paper designs a PPI inhibitor peptide that activates PTP1B by disrupting its interaction with the 14-3-3ζ complex, leading to reduced EGFR phosphorylation and cancer cell viability.
DOI 10.64898/2026.03.19.712938