Sequential HIV-1 fusion protein gates control the initiation of host cell entry
Hung Do, Muralikrishna Lella, Devansh Fulmali, Niva Rajpara, Ilona Christy Unarta, Alexis Johnson, Katarzyna Janowska, Helena Laukaitis, Carrie Saunders, R.J. Edwards, Priyamvada Acharya, Amit Sharma, Sandrasegaram Gnanakaran, Rory C. Henderson
This study identifies two sequential conformational gates in HIV-1 Env that control fusion peptide release and host cell entry initiation.
bioRxiv · Aug 7, 2026 · PreprintMolecular Biology