Xiao Huang

This study uses single-molecule imaging to show peptide inhibitors bind to prefusion viral fusion proteins with varying stoichiometry and rapid kinetics, challenging the canonical prehairpin-intermediate model.

This study identifies features contributing to catalytic efficiency in a de novo enzyme through computational design and directed evolution, showing how stability and dynamics interplay in enzyme optimization.

This study investigates the structural and antigenic diversity of Henipavirus and Parahenipavirus glycoproteins using cryo-EM and crystal structures, revealing new epitopes and insights for vaccine development.

This paper describes a user-managed 100 keV electron microscope setup for structural virology, enabling high-quality cryo-EM data collection and analysis within a laboratory setting.