Author

Muralikrishna Lella

Duke UniversityORCID 0000-0002-7374-9528Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Katarzyna JanowskaiD· 4 shared Priyamvada AcharyaiD· 4 shared Barton F. HaynesiD· 3 shared Alexis Johnson· 2 shared Amit SharmaiD· 2 shared Hung Nguyen DoiD· 2 shared Katayoun MansouriiD· 2 shared Kevin O. SaundersiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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4 shared papersBiochemistry

Katarzyna JanowskaORCID

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Author profile →

4 papers

Recent·Most cited

Anti-HIV-1 B cell antigen receptor signaling and structure

Bhishem Thakur, Jahangir Alam, Kenneth D. Cronin, Parth Patel, Kara M. Anasti, Advaiti Pai Kane, Alamgir Hossain, Hung Nguyen Do, Katayoun Mansouri, Taylor N. Spence, Robert J. Edwards, Rasangi Pathirage, Katarzyna Janowska, Muralikrishna Lella, Aaron Cook, , S. Munir Alam

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

iScience · Nov 1, 2026Peer-reviewedImmunology

Sequential HIV-1 fusion protein gates control the initiation of host cell entry

Hung Do, Muralikrishna Lella, Devansh Fulmali, Niva Rajpara, Ilona Christy Unarta, Alexis Johnson, Katarzyna Janowska, Helena Laukaitis, Carrie Saunders, R.J. Edwards, Priyamvada Acharya, Amit Sharma, Sandrasegaram Gnanakaran, Rory C. Henderson

This study identifies two sequential conformational gates in HIV-1 Env that control fusion peptide release and host cell entry initiation.

bioRxiv · Aug 7, 2026 · PreprintMolecular Biology

Mechanistic and Antigenic Boundaries of Henipavirus and Parahenipavirus Glycoproteins

Aaron J. May, Muralikrishna Lella, Jared J. Lindenberger, Alexander Berkman, Ujjwal Kumar, Kejun Liu, Moumita Dutta, Maggie Barr, Robert Parks, Xiaozhi Lu, Madison Berry, Amanda Powell, Amelia Thompson, Sravya Sowdamini Nakka, Camila Tenorio França, , Priyamvada Acharya

This study investigates the structural and antigenic diversity of Henipavirus and Parahenipavirus glycoproteins using cryo-EM and crystal structures, revealing new epitopes and insights for vaccine development.

Nature Communications · Jun 19, 2026Peer-reviewedBiochemistry

An integrated workflow for structural virology with a 100 keV electron microscope

Rasangi Pathirage, Moumita Dutta, Ruth Parsons, Muralikrishna Lella, Emma Atwood, Qianyi E. Zhang, Aaron May, Alexis Johnson, Xiao Huang, Jordan Flemming, Ujjwal Kumar, Bahjat F. Marayati, M. Ariel Spurrier, Coco Liu, Junlin Zhuo, , Priyamvada Acharya

This paper describes a user-managed 100 keV electron microscope setup for structural virology, enabling high-quality cryo-EM data collection and analysis within a laboratory setting.

bioRxiv · Dec 10, 2025 · PreprintBiochemistry