Amit Sharma

This study shows that HIV-1 envelope glycan loss in SHIVs improves CD4 receptor utilization and reduces IFN restriction, linking receptor adaptation and immune escape.

This study identifies two sequential conformational gates in HIV-1 Env that control fusion peptide release and host cell entry initiation.

This study characterizes the antiviral activities and regulatory mechanisms of diverse IFITM proteins in macaques, showing how gene duplication and retrotransposition generate functional diversity in antiviral defenses.

This paper describes a user-managed 100 keV electron microscope setup for structural virology, enabling high-quality cryo-EM data collection and analysis within a laboratory setting.

This study shows African-lineage Zika virus strains are more resistant to type-I interferon than Asian-lineage strains, and IFITM3 does not fully explain IFN-I restriction.