Katarzyna Janowska

Anti-HIV-1 B cell antigen receptor signaling and structure

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

Peptide inhibitors recognize prefusion viral fusion proteins with heterogeneous stoichiometry and rapid kinetics

This study uses single-molecule imaging to show peptide inhibitors bind to prefusion viral fusion proteins with varying stoichiometry and rapid kinetics, challenging the canonical prehairpin-intermediate model.

Sequential HIV-1 fusion protein gates control the initiation of host cell entry

This study identifies two sequential conformational gates in HIV-1 Env that control fusion peptide release and host cell entry initiation.

Mechanistic and Antigenic Boundaries of Henipavirus and Parahenipavirus Glycoproteins

This study investigates the structural and antigenic diversity of Henipavirus and Parahenipavirus glycoproteins using cryo-EM and crystal structures, revealing new epitopes and insights for vaccine development.

An integrated workflow for structural virology with a 100 keV electron microscope

This paper describes a user-managed 100 keV electron microscope setup for structural virology, enabling high-quality cryo-EM data collection and analysis within a laboratory setting.

Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity

The paper isolates glycan-reactive antibodies from HIV-1 vaccine trial participants and finds they neutralize diverse HIV strains and show broad cross-reactivity against other pathogens.

Design of SARS-CoV-2 RBD Immunogens to Focus Immune Responses Towards Conserved Coronavirus Epitopes

This paper designs SARS-CoV-2 RBD immunogens that shift immune responses towards conserved epitopes, improving cross-reactivity against variants.

Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening

This study visualizes the conformational changes of the HIV-1 fusion peptide during CD4-induced Env opening, showing it remains antibody accessible despite Env opening.

SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition

The paper determines cryo-EM structures of SARS-CoV-2 XBB lineage spike proteins, revealing structural changes that enhance immune evasion and receptor binding.

Structures of Langya virus fusion protein ectodomain in pre and post fusion conformation

The paper determines cryo-EM structures of Langya virus fusion protein in pre- and post-fusion states, revealing structural differences and a potential mechanism for fusion initiation.