Elucidation of the molecular mechanism of the breakage-fusion-bridge (BFB) cycle using a CRISPR-dCas9 cellular model
Manrose Singh, Kaitlin Raseley, Alexis M. Perez, Danny MacKenzie, Settapong T Kosiyatrakul, Sanket Desai, Noelle Batista, Navjot Guru, Katherine Loomba, Heba Zuhair Abid, Yilin Wang, Lars Udo-Bellner, Randy F. Stout, Carl L. Schildkraut, Ming Xiao, Dong Zhang
This study uses a CRISPR-dCas9 model to investigate the BFB cycle, revealing increased DNA damage, chromosome fusions, and involvement of DNA repair pathways in ITCB formation.
Nucleic Acids Research · Aug 28, 2024Peer-reviewedCancer Biology