Cancer BiologyNucleic Acids ResearchPeer-reviewed
Elucidation of the molecular mechanism of the breakage-fusion-bridge (BFB) cycle using a CRISPR-dCas9 cellular model
Manrose Singh, Kaitlin Raseley, Alexis M. Perez…·Dong Zhang
This study uses a CRISPR-dCas9 model to investigate the BFB cycle, revealing increased DNA damage, chromosome fusions, and involvement of DNA repair pathways in ITCB formation.
11 citations