Heba Zuhair Abid

The function of human PIF1 in G quadruplex formation and replication stress response at ALT telomeres

This study investigates the role of human PIF1 in ALT telomere maintenance, showing its involvement in DNA damage, G4 formation, and replication stress response, with implications for cancer therapy.

DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres

This study shows DNA2 and FANCM function in distinct pathways to suppress replication stress at ALT telomeres, with their combined depletion causing synthetic lethality in ALT+ cancers.

Elucidation of the molecular mechanism of the breakage-fusion-bridge (BFB) cycle using a CRISPR-dCas9 cellular model

This study uses a CRISPR-dCas9 model to investigate the BFB cycle, revealing increased DNA damage, chromosome fusions, and involvement of DNA repair pathways in ITCB formation.

Comprehensive Analysis of Human Subtelomeres by Whole Genome Mapping

The paper uses optical mapping to analyze subtelomere structure and variation across 154 human genomes, identifying novel haplotypes and population-specific trends.