Author

Manrose Singh

New York Institute of TechnologyORCID 0000-0002-3636-8531Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Carl L. Schildkraut· 2 shared Dong ZhangiD· 2 shared Heba Zuhair AbidiD· 2 shared Ming XiaoiD· 2 shared Settapong T Kosiyatrakul· 2 shared Alexis M. Perez· 1 shared Ashwin RagupathiiD· 1 shared Benjamin Yusupov· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Carl L. Schildkraut

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 22, 2025

DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres

Ashwin Ragupathi, Heba Zuhair Abid, Yun Chen…·Dong Zhang

This study shows DNA2 and FANCM function in distinct pathways to suppress replication stress at ALT telomeres, with their combined depletion causing synthetic lethality in ALT+ cancers.

1 citation

experimental assaycancer & tumor microenvironment

Cancer BiologyNucleic Acids ResearchPeer-reviewedAug 28, 2024

Elucidation of the molecular mechanism of the breakage-fusion-bridge (BFB) cycle using a CRISPR-dCas9 cellular model

Manrose Singh, Kaitlin Raseley, Alexis M. Perez…·Dong Zhang

This study uses a CRISPR-dCas9 model to investigate the BFB cycle, revealing increased DNA damage, chromosome fusions, and involvement of DNA repair pathways in ITCB formation.

11 citations

humangenetic perturbation / CRISPR