Author

Alfred Kihoon Lee

Montreal Clinical Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Hideto TakahashiiD· 3 shared Nayoung YiiD· 3 shared Benjamin FelleriD· 2 shared Husam KhalediD· 2 shared Nicolas ChoffletiD· 2 shared Aurélie FalloniD· 1 shared Farin B. BourojeniiD· 1 shared Irina ShlaiferiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Hideto TakahashiORCID

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3 papers

Recent·Most cited

SorCS1 promotes synaptic and cognitive resilience despite amyloid pathology in Alzheimer's disease model mice

Nayoung Yi, Alfred Kihoon Lee, Farin B. Bourojeni, Manni Wang, Mai Inagaki, Hideto Takahashi

This study shows that SorCS1 overexpression in Alzheimer's disease model mice preserves cognitive function and synaptic integrity without reducing amyloid levels.

bioRxiv · Aug 27, 2026 · PreprintNeuroscience

α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

Benjamin Feller, Aurélie Fallon, Wen Luo, Phuong Trang Nguyen, Irina Shlaifer, Alfred Kihoon Lee, Nicolas Chofflet, Nayoung Yi, Husam Khaled, Samer Karkout, Steve Bourgault, Thomas M. Durcan, Hideto Takahashi

This study identifies β-neurexins as presynaptic proteins that bind to α-synuclein preformed fibrils, impairing presynaptic organization and contributing to synucleinopathy pathology.

Cells · Apr 4, 2023Peer-reviewedNeuroscience

SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology

Alfred Kihoon Lee, Nayoung Yi, Husam Khaled, Benjamin Feller, Nicolas Chofflet, Hideto Takahashi

This study shows SorCS1 competes with AβOs for binding to NRX1β, rescuing AβO-induced synaptic dysfunction in neurons.

Life Science Alliance · Jan 25, 2023Peer-reviewedNeuroscience