Author

Nayoung Yi

Montreal Clinical Research InstituteORCID 0000-0001-7688-0313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Alfred Kihoon Lee· 3 shared Hideto TakahashiiD· 3 shared Benjamin FelleriD· 2 shared Husam KhalediD· 2 shared Nicolas ChoffletiD· 2 shared Aurélie FalloniD· 1 shared Farin B. BourojeniiD· 1 shared Irina ShlaiferiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Alfred Kihoon Lee

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 27, 2026

SorCS1 promotes synaptic and cognitive resilience despite amyloid pathology in Alzheimer's disease model mice

Nayoung Yi, Alfred Kihoon Lee, Farin B. Bourojeni…·Hideto Takahashi

This study shows that SorCS1 overexpression in Alzheimer's disease model mice preserves cognitive function and synaptic integrity without reducing amyloid levels.

DOI 10.64898/2026.08.24.746580

mouseexperimental assay

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NeuroscienceCellsPeer-reviewedApr 4, 2023

α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

Benjamin Feller, Aurélie Fallon, Wen Luo…·Hideto Takahashi

This study identifies β-neurexins as presynaptic proteins that bind to α-synuclein preformed fibrils, impairing presynaptic organization and contributing to synucleinopathy pathology.

24 citations

humanproteomics

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NeuroscienceLife Science AlliancePeer-reviewedJan 25, 2023

SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology

Alfred Kihoon Lee, Nayoung Yi, Husam Khaled…·Hideto Takahashi

This study shows SorCS1 competes with AβOs for binding to NRX1β, rescuing AβO-induced synaptic dysfunction in neurons.

9 citations

mouseproteomics

𝕏 PostBluesky