Hideto Takahashi

This study shows that SorCS1 overexpression in Alzheimer's disease model mice preserves cognitive function and synaptic integrity without reducing amyloid levels.

The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.

This study identifies β-neurexins as presynaptic proteins that bind to α-synuclein preformed fibrils, impairing presynaptic organization and contributing to synucleinopathy pathology.

This study shows SorCS1 competes with AβOs for binding to NRX1β, rescuing AβO-induced synaptic dysfunction in neurons.

This study shows dopaminergic neurons form a unique axonal arbor with mostly non-synaptic terminals, expressing exocytosis proteins and being active, and highlights the role of specific proteins in synapse formation.