Author

Nicolas Chofflet

Montreal Clinical Research InstituteORCID 0009-0002-9175-1653Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

Benjamin FelleriD· 3 shared Hideto TakahashiiD· 3 shared Alfred Kihoon Lee· 2 shared Husam KhalediD· 2 shared Nayoung YiiD· 2 shared Anders Dupont BørglumiD· 1 shared Aurélie FalloniD· 1 shared Beth A. CiminiiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Benjamin FellerORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation

Mathias Kaas Ollendorff, Nicolas Chofflet, Deniz Bicer, Sune Skeldal, Jinjie Duan, Benjamin Feller, Joachim Vilstrup, Rosa Groth, Suganya Sivagurunathan, Hesam Dashti, Jan Skov Pedersen, Thomas Mears Werge, Anders Dupont Børglum, Beth A. Cimini, Thouis R. Jones, , Simon Glerup

The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.

bioRxiv · Feb 16, 2025 · PreprintNeuroscience

α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

Benjamin Feller, Aurélie Fallon, Wen Luo, Phuong Trang Nguyen, Irina Shlaifer, Alfred Kihoon Lee, Nicolas Chofflet, Nayoung Yi, Husam Khaled, Samer Karkout, Steve Bourgault, Thomas M. Durcan, Hideto Takahashi

This study identifies β-neurexins as presynaptic proteins that bind to α-synuclein preformed fibrils, impairing presynaptic organization and contributing to synucleinopathy pathology.

Cells · Apr 4, 2023Peer-reviewedNeuroscience

SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology

Alfred Kihoon Lee, Nayoung Yi, Husam Khaled, Benjamin Feller, Nicolas Chofflet, Hideto Takahashi

This study shows SorCS1 competes with AβOs for binding to NRX1β, rescuing AβO-induced synaptic dysfunction in neurons.

Life Science Alliance · Jan 25, 2023Peer-reviewedNeuroscience