The role of LEDGF in transcription is exploited by HIV-1 to position integration
Rakesh Pathak, Caroline Esnault, Rajalingam Radhakrishnan, Parmit Kumar Singh, Hongen Zhang, Ryan Dale, Abhishek Anand, Gregory J. Bedwell, Alan Engelman, Ali Rabi, Sahand Hormoz, Priyanka Singh, Henry L. Levin
This study shows LEDGF is recruited to promoters by MLL1 and recruits RNA Pol II, facilitating HIV-1 integration across gene bodies.
bioRxiv · Jun 29, 2024 · PreprintGenomics