Rajalingam Radhakrishnan

Structural and Mechanistic Bases for Resistance of the M66I Capsid Variant to Lenacapavir

This paper investigates how the M66I mutation in HIV-1 capsid protein confers resistance to lenacapavir by altering inhibitor binding and viral replication.

CPSF6 Promotes HIV-1 Preintegration Complex Function

This study shows CPSF6 promotes HIV-1 preintegration complex function by enhancing viral DNA integration into gene-dense regions and restoring integration activity when added back to mutant cells.

Interplay between the cyclophilin homology domain of RANBP2 and MX2 regulates HIV-1 capsid dependencies on nucleoporins

This study shows that the RANBP2-Cyp domain influences HIV-1 infection and MX2 activity by modulating CA interactions with nucleoporins and integration targeting.

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection

This study investigates how the nuclear localization signal (NLS) of CPSF6 influences HIV-1 infection after nuclear import, showing that some NLSs impair viral integration.

The role of LEDGF in transcription is exploited by HIV-1 to position integration

This study shows LEDGF is recruited to promoters by MLL1 and recruits RNA Pol II, facilitating HIV-1 integration across gene bodies.