Sahand Hormoz

Robust axis formation requires both short-range adhesion and long-range attraction

The paper models how short-range adhesion and long-range attraction in gastruloids lead to robust axis formation, supported by experimental validation.

Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathies

This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.

scAI-SNP: a method for inferring ancestry from single-cell data

scAI-SNP infers ancestry from single-cell data using ancestry-informative SNPs, showing robustness across diverse tissues and modalities.

Robustness of Selection and Timing Inference under Model Variation in Population Genetics

This paper analyzes how model mismatches affect the inference of selection coefficients and mutation timing in population genetics, showing that time of onset is sensitive to assumptions about reproductive variance and generations.

The role of LEDGF in transcription is exploited by HIV-1 to position integration

This study shows LEDGF is recruited to promoters by MLL1 and recruits RNA Pol II, facilitating HIV-1 integration across gene bodies.

An improved rhythmicity analysis method using Gaussian Processes detects cell-density dependent circadian oscillations in stem cells

This paper introduces ODeGP, a Gaussian Process-based method for detecting oscillations in time series, and shows it outperforms existing methods in detecting weak and non-stationary rhythms in qPCR data.

Accurate de novo detection of somatic mutations in high-throughput single-cell profiling data sets

SComatic detects somatic mutations in single-cell RNA-seq and ATAC-seq data without bulk DNA sequencing, achieving higher precision than existing methods.

Paraxial mesoderm organoids model development of human somites

This study generates human paraxial mesoderm organoids that form somite-like structures in vitro, enabling analysis of human spinal cord development.

Computing the Riemannian curvature of image patch and single-cell RNA sequencing data manifolds using extrinsic differential geometry

The paper estimates Riemannian curvature of image and scRNA-seq data manifolds using extrinsic differential geometry, revealing curvature in scRNA-seq datasets.

An engineered CRISPR/Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells

The paper introduces a CRISPR/Cas9 mouse line (CARLIN) to simultaneously track lineage histories and gene expression in single cells, revealing clonal bottlenecks in hematopoietic stem cells.