Alice Brion

A nuclear trafficking checkpoint licenses resolution of RNA-DNA hybrids at stalled RNAPII to maintain genome stability under genotoxic stress

The paper shows that genotoxic stress triggers nuclear import of EXD2 to resolve RNA-DNA hybrids at stalled RNAPII, preventing transcription-replication conflicts and maintaining genome stability.

Comparative transcriptomics reveal a novel tardigrade specific DNA binding protein induced in response to ionizing radiation

The paper identifies a novel tardigrade-specific DNA binding protein, TDR1, that enhances resistance to ionizing radiation in human cells.