Laurent Jourdren

The paper identifies astrocyte perisynaptic processes as sites of early translational dysregulation in Alzheimer's disease, linking it to synaptic dysfunction and disease initiation.

This study benchmarks bioinformatics methods for single-cell and spatial RNA-seq Nanopore long-read data, evaluating their accuracy, robustness, and scalability across different protocols and sequencing conditions.

AsaruSim simulates synthetic single-cell Nanopore long-read datasets to evaluate isoform detection methods using human PBMC data.

This study identifies vascular dysfunction as a key contributor to oxaliplatin-induced peripheral neuropathy in mice by showing increased vasoconstriction and hypoxia, which can be mitigated by vasodilators.

The paper identifies a novel tardigrade-specific DNA binding protein, TDR1, that enhances resistance to ionizing radiation in human cells.

Eoulsan 2 updates a workflow manager to support bulk, long-read, and single-cell transcriptomics analyses with improved infrastructure and module development.

This study identifies OTX2's roles in adult choroid plexus function through knockdown models and proteomic analysis, revealing its impact on secretion, immune responses, and RNA processing.

The paper compares molecular and functional maturation of brain vascular cells in mice and humans during postnatal development, identifying key markers and processes in endothelial and vascular smooth muscle cells.

The paper identifies a unique molecular repertoire in hippocampal perisynaptic astrocytic processes, regulated by local translation during fear conditioning.

The paper shows that OTX2 homeoprotein transfer regulates visual cortex plasticity in juvenile mice by modulating Gadd45b/g expression and epigenetic states.