Spatially enforced engagement of PD-1⁺ T cells with AXL⁺ cells reprograms the tumor microenvironment and overcomes anti-PD-1 resistance
Ksenia M. Yegodayev, Gregory Perelman, Tamar Shami, Bar Kaufman, Danialle Raviv, Divyasree Marripati, Aseel Khateeb, Raz Ben-Uri, Oshrat Galibov-Levi, Idan Milo, Alice Raizman, Alona Veinblat, Abraham Nissani, Noam Zuri, Dinesh Babu Manikandan, , Moshe Elkabets
This study develops a bispecific antibody that enhances T-cell engagement with AXL+ cells, improving anti-PD-1 therapy efficacy in HNSCC by remodeling the tumor microenvironment.
bioRxiv · Oct 28, 2026 · PreprintCancer Biology