Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development
Shreeta Chakraborty, Nina Wenzlitschke, Matthew J. Anderson, Ariel Eraso, Manon Baudic, Joyce J. Thompson, Alicia A Evans, Lilly M. Shatford-Adams, Raj Chari, Parirokh Awasthi, Ryan Dale, Mark B. Lewandoski, Timothy J. Petros, Pedro P. Rocha
The paper shows that disrupting chromatin domain boundaries with multiple developmental regulators can cause severe gene dysregulation and developmental defects in mice.
Developmental Cell · Jul 1, 2025Peer-reviewedDevelopmental Biology