Mark B. Lewandoski

This study shows HIF1α regulates intracellular oxygen levels in the presomitic mesoderm, affecting somitogenesis and spine development through metabolic reprogramming.

The paper shows that disrupting chromatin domain boundaries with multiple developmental regulators can cause severe gene dysregulation and developmental defects in mice.

This study shows that age-related changes in the lineage composition of the enteric nervous system affect gut health, with mesoderm-derived neurons becoming dominant and functional effects on intestinal motility that can be reversed by GDNF.

The paper identifies cardiac progenitors as a source of Wnts that regulate second heart field development through secretion, using genetic manipulation and single-cell RNA sequencing in mice.

This study shows that FGF8 promotes nephron progenitor survival by regulating BAX/BAK-mediated apoptosis, partially rescuing kidney development in Fgf8 mutants.

This study shows Fgf4 is essential for maintaining Hes7 levels and Notch oscillations in the somite segmentation clock, leading to vertebral defects in Fgf4 mutants.