A random mutagenesis screen enriched for missense mutations in bacterial effector proteins.
Malene L Urbanus, Thomas M Zheng, Anna N Khusnutdinova, Doreen Banh, Harley O’Connor Mount, Alind Gupta, Peter J Stogios, Alexei Savchenko, Ralph R Isberg, Alexander F Yakunin, Alexander W Ensminger
The paper presents a yeast-based method to identify informative missense mutations in bacterial effector proteins and validates it using three effectors from Legionella pneumophila.
bioRxiv · Mar 14, 2024Microbiology