Stefan Schulz

Relating GPCR domains with functionality: receptor helix-bundle and C-terminus differentially influence GRK-specific functions and β-arrestin-mediated regulation

The paper investigates how GPCR domains influence β-arrestin functions and conformational changes, revealing domain-specific effects on signaling outcomes.

Opioid-Induced Inter-regional Dysconnectivity Correlates with Analgesia in Awake Mouse Brains

This study examines opioid-induced changes in brain activation and functional connectivity in awake mice, finding that dysconnectivity correlates with analgesia.

Chronic morphine induces adaptations in opioid receptor signaling in a thalamo-cortico-striatal circuit that are projection-dependent, sex-specific and regulated by mu opioid receptor phosphorylation

This study shows chronic morphine induces sex-specific, projection-dependent adaptations in MOR signaling in thalamo-cortico-striatal circuits, mediated by MOR phosphorylation.

Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid beta-degrading enzyme, in brain

This study identifies SST1 and SST4 as redundant regulators of neprilysin, a key amyloid beta-degrading enzyme, and shows that targeting these receptors reduces Aβ pathology and improves cognition in an AD mouse model.

Heteromerization of endogenous mu and delta opioid receptors tunes mu opioid receptor signaling and trafficking

This study investigates mu-delta opioid receptor heteromerization in neurons, showing co-internalization and altered trafficking, with implications for nociceptive transmission.