Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions
Mohammad El Kadri, Fabien Guegan, Parul Sharma, Estefanía Calvo Álvarez, Erika Pineda, Pauline Morand, Jean Marc Tsagmo Ngoune, Justine Escard, Jean‐William Dupuy, Aline Rimoldi, Nicolas Plazolles, Edern Cahoreau, Marc Biran, Michael Peter Barrett, Luísa M. Figueiredo, , Frédéric Bringaud
This study identifies glycerol as a trigger for Trypanosoma brucei differentiation into transmissible forms under tissue-like conditions, challenging the traditional bloodstream model of transmission.
Nature Communications · Jul 17, 2026Peer-reviewedMicrobiology