Author

Nicolas Plazolles

Centre National de la Recherche ScientifiqueORCID 0000-0002-7186-3765Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Aline Rimoldi· 2 shared Edern CahoreauiD· 2 shared Erika PinedaiD· 2 shared Frédéric BringaudiD· 2 shared Marc BiraniD· 2 shared Mohammad El KadriiD· 2 shared Brice RotureauiD· 1 shared Corinne AsencioiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMicrobiology

Aline Rimoldi

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions

Mohammad El Kadri, Fabien Guegan, Parul Sharma, Estefanía Calvo Álvarez, Erika Pineda, Pauline Morand, Jean Marc Tsagmo Ngoune, Justine Escard, Jean‐William Dupuy, Aline Rimoldi, Nicolas Plazolles, Edern Cahoreau, Marc Biran, Michael Peter Barrett, Luísa M. Figueiredo, , Frédéric Bringaud

This study identifies glycerol as a trigger for Trypanosoma brucei differentiation into transmissible forms under tissue-like conditions, challenging the traditional bloodstream model of transmission.

Nature Communications · Jul 17, 2026Peer-reviewedMicrobiology

The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei operates in the gluconeogenic direction in cellulo under in vivo-like conditions

Nicolas Plazolles, Hanna Kulyk, Edern Cahoreau, Marc Biran, Marion Wargnies, Erika Pineda, Mohammad El Kadri, Aline Rimoldi, Perrine Hervé, Corinne Asencio, Loïc Rivière, Paul A.M. Michels, D.K. Inaoka, Emmanuel Tétaud, Jean‐Charles Portais, Frédéric Bringaud

This paper shows that ATP-dependent phosphofructokinase (PFK) in Trypanosoma brucei functions gluconeogenically in vivo, challenging its traditional role in glycolysis.

PLoS Biology · May 16, 2025Peer-reviewedMicrobiology