Jean‐Charles Portais

The paper introduces the concept of the cellular electron economy to quantify and organize electron flow across metabolism in microorganisms, revealing how carbon sources and electron disposal capacity shape metabolic organization.

This paper shows that ATP-dependent phosphofructokinase (PFK) in Trypanosoma brucei functions gluconeogenically in vivo, challenging its traditional role in glycolysis.

PhysioFit quantifies cell growth parameters and extracellular fluxes using flexible growth models and provides a user-friendly software tool for non-computational biologists.

IsoSolve integrates isotopic measurements from MS and NMR to improve isotopic coverage and consolidate data for metabolic network analysis.

This study develops a kinetic model of E. coli metabolism to explain acetate overflow, showing acetate regulates glucose metabolism and is not a wasteful by-product.

ScalaFlux quantifies metabolic fluxes in subnetworks without requiring external network information, validated on yeast mutants and simulated data.