A model of apical-out human first trimester trophoblast organoids to study regeneration after syncytial damage
Ida Calvi, Giada Guntri, Lhéanna Klaeylé, Alexandra Graff Meyer, Karolina Guja-Jarosz, Qian Li, Isabel Filges, Belinda Gewitsch, Aline Thommen, Thomas Menter, Olav Lapaire, Jan Seebacher, Hans-Rudolf Hotz, Naomi N. McGovern, Margherita Yayoi Turco
The paper develops an in vitro model of human first-trimester trophoblast organoids to study syncytiotrophoblast regeneration after damage and identifies TNFRSF12A as a potential enhancer of this process.
bioRxiv · Oct 21, 2025 · PreprintDevelopmental Biology