Naomi N. McGovern

This study integrates single-cell data to create a unified framework of human placental development, revealing cell subtypes, vascular niches, and trophoblast dynamics across gestation.

The paper develops an in vitro model of human first-trimester trophoblast organoids to study syncytiotrophoblast regeneration after damage and identifies TNFRSF12A as a potential enhancer of this process.

The paper identifies a uNK-derived cytokine signal that promotes trophoblast differentiation and influences placental function and pregnancy outcomes.