Therapeutic window for treatment of prion disease defined by timed depletion of Prion protein
Barry Matthew Bradford, Alison Marshall, Nadia L. Tuzi, Deborah Brown, Dorothy Kisielewski, KIM M. SUMMERS, Victor Hugh Perry, Pedro Piccardo, Alan Richard Clarke, Jean C. Manson
This study defines a therapeutic window for prion disease by showing early Prnp depletion halts progression, but later depletion does not, using a mouse model with time-dependent Prnp manipulation.
bioRxiv · Nov 18, 2024 · PreprintNeuroscience