Victor Hugh Perry

This study defines a therapeutic window for prion disease by showing early Prnp depletion halts progression, but later depletion does not, using a mouse model with time-dependent Prnp manipulation.

This study shows that activating the WldS pathway can prevent tau-mediated axonal degeneration in a Drosophila model, even when initiated after degeneration has started.

This study evaluates IL-34 inhibition as a strategy to reduce microglial proliferation in prion disease, showing tissue-selectivity and reduced side effects compared to CSF1R inhibition.

The paper shows an age-dependent decline in GluN2B-containing NMDA receptors in human cortical synapses, potentially contributing to age-related cognitive decline.

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.